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- Sony Biotechnology
- Sony Biotechnology
FcγRIV, also known as CD16.2, is an intermediate-affinity activating receptor for IgG2a and IgG2b. CD16.2 is the mouse homolog of human FcγRIIIA. CD16.2 is a low-affinity IgE receptor for all allotypes and the ligation of FcγRIV by antigen-IgE immune complexes promotes macrophage-mediated phagocytosis and is involved in lung inflammation.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 microg per million cells in 100 microL volume. For immunohistochemical staining on formalin-fixed paraffin-embedded tissue sections, the suggested use of this reagent is 5.0 - 10 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
1. Mancardi DA, et al. 2008. J. Clin. Invest 118:3738. (FC, Block)
2. Nimmerjahn F, et al. 2005. Immunity 23:41.