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Bacteria, most notably the gut microbiome, have gained increased attention for their role in agriculture and human disease. However study of individual bacterium can be challenging since most bacteria do not grow under simple culture conditions. In a recent study, Blow, et al. have published a draft sequence of the bacteria, Candidatus Erwinia dacicola (Enterobacteriaceae). This bacteria has a symbiotic relationship with t...
Base editing: a scientific breakthrough
CRISPR genomics tools offer substantial therapeutic potential due to their precision, adaptability, and unparalleled genome-editing accuracy. Base editing is an valuable technique within this landscape, enabling the meticulous alteration of individual DNA bases—adenine, guanine, cytosine, or thymine—within a target DNA sequence without causing disruptive double-strand breaks [1]. ...
Presented by Select Science
In recent years, cell-based therapies have been tremendously successful in treating hematologic malignancies. Efforts have continued to expand treatment to other chronic diseases. However, the underlying genetic state and therapeutic functions of these cells, such as secretion of cytokines, are still not well understood. New approaches to analyze and sort live, intact cells based on combin...
Presented by SelectScience
A comprehensive picture of somatic cell clonal evolution driving tumorigenesis is not possible with bulk sequencing strategies that fail to uncover rare alleles. Single-cell analysis provides the fundamental unit of resolution to define this evolution, but existing methods to amplify the genomes of single cells suffer from poor genomic coverage, uniformity, and allelic balance. The ResolveD...