Description

T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ is involved in the recognition of certain bacterial, self-CD1 molecule, and tumor antigens bound to MHC class I. The γ/δ TCR associates with CD3 and is expressed on a subset of T cells found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4^-/CD8^-, some are CD8⁺. T cells expressing the γ/δ TCR have been shown to play a role in oral tolerance, innate immune response for some tumor cells, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation.

Formulation

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Rodriguez-Gago M, et al. 2001. Transplantation. 72:503.
2. Lehmann FS, et al. 2002. Am. J. Physiol. Gastrointest. Liver. Physiol. 283:G481. (FC)
3. Bordignon M, et al. 2008. Mol. Med. Rep. 1:485. (IHC)
4. Conrad M, et al. 2007. Cytom. Part A 71A:925. (FC)
5. Pollinger B, et al. 2011. J. Immunol. 186:2602. (IHC)
6. Correia DV, et al. 2011. Blood. 118:992. (Block)
7. Laurent AJ, et al. 2014. PLoS One. 9:103683. PubMed