Purified anti-human CD366 (Tim-3)

Antibodies Single
Sony
F38-2E2
Flow Cytometry
Mouse IgG1, κ
Human
Human Tim-3 fusion protein
2325005
$116.00

Description

CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Hastings WD, et al. 2009. Eur. J. Immunol. 39:2492. (Costim)
2. Jones RB, et al. 2008. J. Exp. Med. 205:2763. (Block)
3. Klibi J, et al 2009. Blood 113:1957. (FC, Block)