Description

CD150 is a 70-95 kD type I transmembrane glycoprotein also known as SLAM or IPO-3. It is a member of the Ig superfamily. It is expressed on a subset of T cells, B cells, dendritic cells, and endothelial cells. The expression of CD150 is upregulated upon activation. CD150 binds to itself as the ligand to be involved in B cell costimulation, proliferation, immunoglobulin production, and signal transduction.

Formulation

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 microg per 10⁶ cells in 100 microL volume or 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Garcia V, et al. 2001. J. Immunol. 167:5719. (Costim)
2. Vincent S, et al. 2002. J. Virol. 76:6121.
3. Cocks B, et al. 1995. Nature 376:260.
4. Sayos J, et al. 2001. Blood 97:3867. (IP)
5. Aversa G, et al. 1997. J. Immunol. 158:4036. (Costim)
6. Spencer M, et al. 2010. Am. J. Physiol Endocrinol Metab. 299:1016. PubMed