Purified anti-human CD134 (OX40)

Antibodies Single
Sony
Ber-ACT35 (ACT35)
Other
Mouse IgG1, κ
Human
HTLV 1-transformed HUT 102 cells
100 µg
2350010

Description

CD134, also known as OX40 and TNFRSF4, is a 50 kD type I transmembrane glycoprotein. It is a member of the TNF receptor family. OX40 is expressed on activated T lymphocytes including Th1, Th2, Th17, and Treg cells. The interaction of OX40 with OX40L results in B cell proliferation and antibody secretion, regulation of primary T cell expansion, and T cell survival. OX40 influences the size of the T cell memory pool and regulation of CD4+ T cell tolerance.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Latza U, et al. 1994. Eur. J. Immunol. 24:677. (WB, IP)
2. Durkop H, et al. 1995. Brit. J. Haematol. 91:927. (IHC)
3. Durkop H, et al. 1997. Brit. J. Haematol. 98:863. (IHC)
4. Willett B, et al. 2007. J. Virol. 81:9665. (ELISA)
5. Li M and Zhang Y. et al. 2005. Cell. Mol. Immunol. 2:467. (FA)
6. Gloviczki ML, et al. 2012. Clin. J. Am. Soc. Nephrol. 8:546. PubMed
7. Domingos PL, et al. 2012. An. Bras. Dermatol. 87:851. (IHC)