Purified anti-human CD123

Antibodies Single
Sony
6H6
Other
Mouse IgG1, κ
Human
Human IL-3Rα transfected COS cells.
100 µg
2130010
$104.00

Description

CD123 is the 70 kD transmembrane α chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity; when CD123 associates with CDw131 (common β chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the β chain for this function. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 microg per million cells in 100 microL volume or 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Sun Q, et al. 1996. Blood 87:83. (IP, WB)
2. Herling M, et al. 2003. Blood 101:5007. (IHC)
3. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
4. Martin-Gayo E, et al. 2010. Blood 115:5366. PubMed
5. Chen SC, et al. 2010. Arch Dermatol Res. 302:113. PubMed
6. Liu Y, et al. 2012. Food Chem Toxicol. 50:1920. PubMed 
7. Peduzzi E, et al. 2007. J. Invest. Dermatol. 127:638. (IHC)