PE anti-human CD210 (IL-10 R)
Description
CD210, also known as the IL-10 receptor, is a 90-110 kD protein expressed on T cells, B cells, NK cells, monocytes and macrophages. CD210 belongs to the class II cytokine receptor family which includes the IFN-γ receptor (CDw119), the IFN-α/β receptor (CD118) and tissue factor (CD142). The IL-10 receptor is involved in signal transduction by inducing phosphorylation of STAT1a and STAT3 and by inducing activation of Jak1 and Tyk.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 microL to 5 microL per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microL staining volume or per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
References
1. Liu Y, et al. 1997. J. Immunol. 158:604. (Immunogen, IP, Block)
2. Levings MK, et al. 2005. Blood 105:1162. (Block)
3. Goodier MR, et al. 2000. J. Immunol. 165:139. (Block)
4. Huang YH, et al. 2009. J. Leukoc. Biol. 86:273. PubMed
5. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
6. Liu BS,et al. 2011. J Leukoc Biol. 89:981. PubMed
7. Joffe M, et al. 2012. Int Immunol. 24:447. PubMed
8. MacDonald KP, et al. 1999. J. Immunol. 163:5599. (epitope)