Biotin anti-human CD39

Antibodies Single
Sony
A1
Flow Cytometry,Immunohistochemistry
Mouse IgG1, κ
Human
PHA activated human lymphocytes
100 µg
2241020
$208.00

Description

Human CD39 is an integral membrane protein with two transmembrane domains. It exists as a homotetramer. Expression of CD39 is found on activated lymphocytes, a subset of T cells and B cells, and dendritic cells with weak staining on monocytes and granulocytes. CD39 and CD73 have been found on regulatory T cells, specifically the effector/memory like T cells. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs). CD39 has intrinsic ecto-ATPase activity. Expression of CD39 is induced on T cells and increased on B cells as a late activation antigen.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Aversa GG, et al. 1988. Transplant. P. 20:4952.
2. Aversa GG, et al. 1989. Transplant. P. 21:34950.
3. Borsellino G, et al. 2007. Blood. 110:1225. (Block)
4. Stockl J, et al. 2001. J. Immunol. 167:2724. (IF)
5. Sestak K, et al. 2007. Vet. Immunol. Immunopathol. 119:21.
6. Lyck L, et al. 2008. J. Histochem. Cytochem. 56:201. (IHC)