APC anti-human CD85a (ILT5)
Description
CD85 is a group of Ig superfamily tansmembrane glycoproteins called Ig-Like Transcripts (ILTs) or Leukocyte Immunoglobulin-like Receptors (LIRs). CD85a is the 110kD member, known as ILT5, LIR-3, or HL9. ILT5 structurally has four extracellular Ig domains and 4 ITIMs in its cytoplasmic tail that provide inhibitory signals. ILT5 is found on the surface of Monocytes/macrophages, granulocytes, NK cells and T-cell subset. ILT5 provides inhibitory signals through interaction with MHC class I molecules.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells or 5 µl per 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
References
1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley & Sons Inc, Publication
2. Sloane DE, et al. 2004. Blood 104:2832
3. Colonna M, et al. 1998