Purified anti-mouse CD1d (CD1.1, Ly-38)

Antibodies Single
Sony
1B1
Other
Rat IgG2b, κ
Mouse
Mouse Cd1.1 cDNA-transfected RMA-S mouse T lymphoma
500 µg
1217510
$267.00

Description

CD1d, known as CD1.1 and Ly-38, is a 48 kD type I membrane glycoprotein with structural similarities to MHC class I and is non-covalently associated with β2-microglobulin. In humans, CD1 family consists of group I proteins (CD1a, CD1b, and CD1c), group II (CD1d), and group III (CD1e). But CD1d is the only CD1 molecule has been found in mouse. Mouse CD1d has broad tissue distribution, and is found on leukocytes, dendritic cells, epithelial cells, and thymocytes. CD1d plays a role in non-peptide glycolipid antigen presentation to CD1d-restricted T cells. It has been shown that PKCδ is a critical regulator of CD1d-mediated antigen presentation.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Fischer K, et al. 2004. P. Natl. Acad. Sci. USA 101:10685. (Block)
2. Brozovic S, et al. 2004. Nat. Med. 10:535.
3. Brossay L, et al. 1997. J. Immunol.. 159:1216. (Block)
4. Jiang J, et al. 2012. PLoS One. 7:47487. PubMed