PE anti-mouse CD365 (Tim-1)

Antibodies Single
Sony
RMT1-4
Flow Cytometry
Rat IgG2b, κ
Mouse
1197530
$388.00

Description

CD365 (Tim-1) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-1 and hepatitis virus cellular receptor 1. It is developmentally expressed at high levels in the blastocyst. Tim-1 is expressed on activated CD4+ lymphocytes especially on Th2 cells and has been implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-1 is hepatitis A virus receptor in humans. Tim-4 is the endogenous ligand of Tim-1. The interaction of Tim-1 and Tim-4 is involved in costimulation of T cell proliferation.  Tim-1 is an endogenous ligand for LMIR5/CD300b.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 microg per 106 cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance in each application.

References

1. Meyers JH, et al. 2005. Nat. Immunol. 6:455.
2. Nakae S, et al. 2007. Blood doi:10.1182/blood-2006-11-058800.
3. Yamanishi Y, et. al. 2010. J. Exp. Med. 207:1501. (FC) 
4. Namavari A, et al. 2012. Invest Ophthalmol Vis Sci. 53:4575. PubMed.