PE anti-human TCR γ/δ

Antibodies Single
Sony
B1
Flow Cytometry
Mouse IgG1, κ
Human
2256050
$255.00

Description

T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ is involved in the recognition of certain bacterial, self-CD1 molecule, and tumor antigens bound to MHC class I. The γ/δ TCR associates with CD3 and is expressed on a subset of T cells found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, some are CD8+. T cells expressing the γ/δ TCR have been shown to play a role in oral tolerance, innate immune response for some tumor cells, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 microL to 5 microL per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microL staining volume or per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Rodriguez-Gago M, et al. 2001. Transplantation. 72:503.
2. Lehmann FS, et al. 2002. Am. J. Physiol. Gastrointest. Liver. Physiol. 283:G481. (FC)
3. Bordignon M, et al. 2008. Mol. Med. Rep. 1:485. (IHC)
4. Conrad M, et al. 2007. Cytom. Part A 71A:925. (FC)
5. Pollinger B, et al. 2011. J. Immunol. 186:2602. (IHC)
6. Correia DV, et al. 2011. Blood. 118:992. (Block)
7. Laurent AJ, et al. 2014. PLoS One. 9:103683. PubMed