-
Sign In
- Sony Biotechnology
- Sony Biotechnology
B-cell lymphoma 6 (Bcl-6), is an 80 kD homodimer, member of the BTB-POZ zinc finger family. It contains 1 BTB (POZ) domain and 6 C2H2-type zinc fingers. Bcl-6 is a transcriptional repressor, master regulator of germinal center reaction. On B cells, Bcl-6 induces proliferation, antibody class switch and affinity maturation, while inhibits its differentiation to plasma cells. On T cells, Bcl-6 induces its differentiation to TFH. This molecule is also expressed in some B cell lymphomas and breast cancer cells.
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining using our nuclear factor staining protocol. For flow cytometric staining, the suggested use of this reagent is 5 microL per million cells or 5 microL per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
1. Vikstrom, et al. 2010. Science 330:1095. (WB)
2. Kallies A, et al. 2011. Blood 117:1869. (WB)
3. Lüthje K, et al. 2012. Nat. Immunol. 13:491. (WB)
4. Tonti E, et al. 2012. J. Immunol. 188:3217. (ICFC)