PE anti-human CD44 isoform 9 (CD44v9)
Description
CD44 isoform 9, also known as CD44v9, is a CD44 isofom consisting of exons 1-5, 13 (v9) and 15 to 19, product of alternative splicing. CD44v9 is expressed by cancer stem cells, epithelial-type carcinomas, subsets of monocytes and subsets of lymphocytes; have a role in tumor initiation, maintenance and metastasis of cancer cells. CD44v9 interacts with the glutamate-cystine transporter xCT, increasing reduced glutathione and contributing to the ROS resistance of cancer cells, and is a potential predictive marker for recurrence of some cancers and a potential therapeutic target.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
References
- Kakehashi, A., et al. 2016. Cancer Sci. 107: 609. (IHC-P)
- Aso T, et al. 2015. PLoS One. 10: e0116596. (IHC-P)
- Yoshikawa M, et al. 2013. Cancer Res. 73: 1855. (IHC-F)
- Ishimoto T, et al. 2011. Cancer Cell. 387-400. (IHC-P)