Empower Precision for Single Cell Analysis

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Single cell RNA analysis (scRNA) technologies have emerged as powerful tools for in-depth analysis of cellular heterogeneity of different cell types and rare populations. Recent advances in multiomics have enabled the simultaneous analysis of the genome, transcriptome, epigenome, and proteome.

The high sensitivity of scRNA seq often leads to sequencing noise contributed by RNA from debris or due to low or undetectable signals in instances where rare cells are of interest. Therefore, careful processing of cells and sample optimization are critical to ensuring that the results truly reflect the cellular state.


Navigate the resources below to learn more about cell sorting in single cell genomics.


Cell Sorting and Genomics Research

Optimize your genomics workflows with plug-and-play sorting

Sony cell sorters have been used for optimizing samples for scRNA seq in several research areas spanning epigenomics, cancer biology, immune cell profiling, neuroscience, and cell atlas mapping, to synthetic biology and gene editing. Delivering both precision and throughput, the Sony sorter can sort the most challenging cell types to deliver samples that give quality scRNA seq results. Download the Publications List →

In these studies, the Sony sorter was used to:

  • Enrich viable cells or intact nuclei and avoid sequencing of extracellular RNA that can increase background noise
  • Purify target subsets using extracellular epitope markers to increase target cell abundance for in-depth single cell profiling

Sony sorters offer key benefits that make them a seamless addition to your genomics research workflow:

  • Automated setup – Designed for novice users who need a system that is easy to learn, use, and teach.
  • Versatile design – Patented optics can detect cells from 0.5–30 micron, resolving viable cells and intact nuclei from debris and supporting analysis of cell subsets stained with 1–12 fluorescence markers.
  • Microfluidics sorting chips – Chips in a range of sizes can sort different cell types at high throughput to deliver target populations with purity >98% and yield >80%. Chips can be optionally exchanged in between experiments or users to eliminate carryover of extraneous RNA.
  • Precise plate sorting – Supports efficient single cell sorting and indexing for isolation of complex or rare cells in 96- and 384-well PCR plates.

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Research labs have successfully integrated the SH800 cell sorter from Sony for single cell epigenomics, antibody discovery, cell development, and more.

Learn more about these applications →

Considering bringing cell sorting to your genomics workflow but unsure where to start? This Best Practices webinar will help you plan for sorting of nuclei, large cells, and immune cells for sequencing experiments.

Watch Best Practices webinar →

Scientists have used cell sorting to advance their work in epigenomics, antibody discovery, gene editing, and cancer. They share their insights and cover key topics from cell sorting tips to analysis of sequencing data.

Browse additional webinars on cell sorting and genomics research →


Sony Solutions

SH800 Cell Sorter

The SH800 automated cell sorter is ideal for users of all expertise levels looking to refine their genomics workflows. With a range of microfluidics chips, isolating viable cells of different sizes or enriching a target cell lineage is easy. With automated setup and proven ease of use, the SH800 sorter can empower you to reach your goals.

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MA900 Multi-Application Cell Sorter

The MA900 multi-application cell sorter is a compact, automated, and easy-to-use system designed to support sorting of panels with up to 12 fluorescence and 2 scatter parameters.
With a choice of 14 parameters and 3 sorting chips, researchers can reliably sort different cells into microtiter plates or 4-way tubes.Gentle microfluidics, onboard cooling, and guided software workflows ensure that the sort outcome is optimal for your unique applications.

Brochure →

 


Resources

Application Highlights

Barcoding Nuclei to Illuminate Single-Cell Epigenetics →
Immune Repertoire Profiling for Antibody Discovery →
Modeling Cardiac Abnormalities in Stem Cell-Derived Cardiomyocytes →

Publications List

Research Publications Featuring Sony Cell Sorter Technology in Single Cell RNA Sequencing Studies →

Webinars

Best Practices Webinars

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Best Practices for Choosing a Method for Single Cell Genomic Analysis

Best practices on how to choose the right method for your study by reviewing the experiment workflow from sample processing to sequencing and data analysis.
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Cell Sorting and Genomics Research Webinars

Diagram of cytokine

Combinatorial Indexing: A High-Throughput Scalable Approach for Exploring Single-Cell Epigenomics

Learn how to optimize and deploy Single-Cell Combinatorial Indexing to profile cells from different tissue types.
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Diagram of cytokine

From Large Cells to Nuclei—Key Considerations for Everyday Sorting Applications

Understand key considerations for setting up sorting experiments with a focus on optimizing sample prep, instrument parameters, and post-sort analysis.
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Diagram of cytokine

Uncovering Cell Type-specific Gene Regulation in Mammalian Tissues using Single Cell Genomics

Discover the latest approaches in single nucleus transcriptomics and ATAC-Seq, and how they can be used on flash-frozen primary human and mouse tissues to decipher tissue-specific epigenetic regulation.
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Diagram of cytokine

Using Double Emulsion Droplet Sorting—Strategies and Applications for Multiomic Profiling

Gain understanding of how cell sorting can be integrated into workflows for multiomic analysis of double emulsion microdroplets.
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For non-clinical research use only. Not for use in diagnostic or therapeutic procedures, or for any other clinical purpose. The SH800 cell sorter is classified as a Class 1 laser product.