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- Sony Biotechnology
Mac-3 is a 110 kD type I membrane glycoprotein, also known as CD107b and LAMP-2. It is expressed on lysosomal membranes and the plasma membrane of macrophages and some myeloid cell lines. In the bone marrow, few cells display Mac-3 antigen on the surface, but a large proportion express Mac-3 in the cytoplasm. CD107b has been identified as a ligand for galaptin, an S-type lectin present in the extracellular matrix. Mac-3/CD107b is upregulated in some tumors and increased expression has been correlated with enhanced metastatic potential.
1. Springer TA. 1981. J. Biol. Chem. 256:3833. (IP)
2. Ho MK, et al. 1983. J. Biol. Chem. 258:636. (IP)
3. Chen JW, et al. 1985. J. Cell Biol. 101:85. (IP)
4. Ralph P, et al. 1983. J. Immunol. 130:108. (IP)
5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
6. Kano M, et al. 1998. Transplantation 65:837. (IHC)
7. Terrazas LI,et al.2005. Int J Parasitol. 35:1349. PubMed
8. Hayashida A, et al. 2011. J. Biol Chem. 286:3288. PubMed
9. Vollmar P, et al. 2010. J. Immunol. 185:6338. (IHC)
10. Odorisio T, et al. 2002. J. Cell Sci. 115:2559. (IHC)
11. Nessler S, et al. 2007. Brain 130:2186. (IHC)