Description

CD5, also known as Leu-1, Ly-1 and T1, is a 67 kD single chain type I glycoprotein that is a member of the scavenger receptor superfamily. CD5 is expressed on T cells, thymocytes, B cell subsets, chronic B lymphocytic leukemia (B-Cells), and peripheral blood dendritic cells. CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T-B cell interactions. One of its ligands is CD72.

Formulation

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. McAlister MS, et al. 1998. Protein Eng. 11:847. (IP)
2. Butmarc JR, et al. 1998. Am. J. Clin. Pathol. 109:682. (IHC)
3. Engleman EG, et al. 1981. Proc. Natl. Acad. Sci. USA 78:1791. (IHC, IP)
4. Ledbetter JA, et al. 1981. J. Exp. Med. 153:310. (FC, IP)
5. Warnke R and Levy R. 1980. J. Histochem. Cytochem. 28:771. (IHC)