-
Sign In
- Sony Biotechnology
- Sony Biotechnology
Mouse CD244, also known as 2B4, is a receptor belonging to the CD2 family of proteins involved in non- MHC-restricted cytotoxicity. It is expressed on all natural killer (NK) cells, IL-2 activated NK (LAK) cells, NKT cells, and a subset of T lymphocytes, including dendritic epidermal T cells. There are at least two isoforms of CD244.2 proteins that differ in the length of the cytoplasmic domain. The long form functions in an inhibitory manner, while the short form functions in an activating manner. The ligand of CD244 is CD48, which is expressed on all hematopoietic cells. It was reported that CD244 interaction with CD48 is essential for IL-2-driven expansion and activation of murine NK cells.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.
1. Lee KM, et al. 2006. Blood. 107:3181.
2. Schatzle JD, et al. 1999. P. Natl Acad Sci USA. 96:3870.
3. Stepp SE, et al. 1999. Eur. J. Immunol. 29:2392.
4. de la Luz Sierra M, et al. 2010. Blood. 115:3970. PubMed