APC anti-human CD158b (KIR2DL2/L3, NKAT2)

Antibodies Single
Sony
DX27
Flow Cytometry
Mouse IgG2a, κ
Human
2163060
$278.00

Description

CD158b is expressed on natural killer cells and a subset of T cells. It is a member of the immunoglobulin superfamily containing two immunoglobulin C2-type domains. Both variants and alternative isoforms of CD158b have been reported. The interaction of CD158b with specific HLA-C antigens on a target cell (HLA-Cw1, HLA-Cw3, HLA-Cw7 alleles, for example) inhibits cytotoxicity and prevents target cell lysis and death. The interactions between KIR and MHC class I are thought to be important in NK cell and T cell regulation following antigen stimulation. The absence of ligands for KIRs may lower the threshold for activation through activating receptors and increase inflammation and susceptibility to autoimmune disease.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 microL per million cells or 5 microL per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Bakker ABH, et al. 1998. J. Immunol. 160:5239.
2. Lucas M, et al. 2003. J. Virol. 77:2251.
3. Goodier M, et al. 2000. J. Immunol. 165:139.
4. Yawata M, et al. 2002. Immunogenetics 54:543.
5. Valiante NM, et al. 1997. Immunity 7:739.