PE anti-mouse/rat CD61

Antibodies Single
Sony
2C9.G2 (HMβ3-1)
Flow Cytometry
Hamster IgG
Mouse,Rat
Vitronectin receptor protein from the mouse T-cell hybridoma 2B4
1121540
$301.00

Description

CD61 is a 110 kD integrin β chain also known as β3 integrin or gpIIIa. It associates with the integrin αv chain (CD51) to form the vitronectin receptor. In addition, CD61 can associate with the integrin αIIb chain (CD41) to form the gpIIb/IIIa complex. CD61 is expressed on platelets, megakaryocytes, endothelium, smooth muscle, a subset of B cells, myeloid cells, osteoclasts, and mast cells. CD61, in conjunction with CD41 or CD51, mediates adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is mediated by the binding of αv3 integrin or vitronectin receptor to CD31 (PECAM-1).

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 microg per 106 cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

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4. Schultz JF, et al. 1995. J. Biol. Chem. 270:11522. (Block)
5. Moulder K, et al. 1991. J. Exp. Med. 173:343. (Activ)
6. Carlson TR, et al. 2008.135:2193. PubMed
7. Yamaji D, et al. 2009. Genes Dev. 23:2382. PubMed