PE/Cy7 anti-mouse CD304 (Neuropilin-1)

Antibodies Single
Sony
3E12
Flow Cytometry
Rat IgG2a, κ
Mouse
Extracellular region of mouse CD304
1326055
$174.00

Description

CD304, also known as neuropilin-1, is a 140 kD type I transmembrane protein. Its extracellular region contains two CUB, two FV/FVIII, and one MAM domain. It is expressed by natural regulatory T cells (nTreg), a subset of invariant natural killer T cells (iNKT), endothelial cells, and neurons. Neuropilin-1 stabilizes the interaction between Tregs and dendritic cells, contributes to the recruitment of tumor-infiltrating Tregs in response to tumor-derived VEGF, and influences the process of angiogenesis and axon guidance. The ligands of CD304 are VEGF165 and semaphorin-3A.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
2. Verhagen J and Wraith DC. 2014. J. Immunol. Methods. S0022. (FC) PubMed
3. Verhagen J, et al. 2014. PLoS One. 9e:108023. (FC) PubMed