Purified anti-human B7-H4

Antibodies Single
Sony
MIH43
Flow Cytometry,Immunohistochemistry
Mouse IgG1, κ
Human
2390505
$104.00

Description

B7-H4, also known as VTCN1, is a type I transmembrane protein and member of the B7 family. Its extracellular region consists of one IgV-like and one IgC-like domain. B7-H4 expression has been reported on activated T cells, B cells, monocytes, and dendritic cells. On T cells, B7-H4 inhibits proliferation, cytokine secretion, and cytotoxicity. B7-H4 is also expressed by different carcinomas including renal, gastric, breast, ovarian and melanoma. Its expression is associated with a poor prognosis.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Quandt D, et al. 2011. Clin. Cancer Res. 17:3100. (IHC)
2. Smith JB, et al. 2014. Gynecol. Oncol. 134:181. (FC, IF, IHC)