APC/Cy7 anti-human IgD

Antibodies Single
Sony
IA6-2
Flow Cytometry
Mouse IgG2a, κ
Human
Human IgD
2341085
$157.00

Description

IgD, a member of the immunoglobulin (Ig) family, is expressed in naïve B cells. It has 3 Ig-like domains and exists in a transmembrane and a soluble form. In general, IgD is not secreted and usually its expression is lost after the Ig isotype switch. After antigen binding, IgD signals through the CD79a/CD79b (Igα/Igβ) heterodimer, resulting in the activation of the B cell.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 microL per million cells or 5 microL per 100 microL of whole blood.  It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Chen K, et al. 2009. Nat. Immunol. 10:889.
2. Lee CH, et al. 2005. J. Exp. Med. 203:63.
3. Sutter JA, et al. 2008. Clin. Immunol. 126:282.
4. Li H and Pauza CD. 2015. Eur. J. Immunol. 45:298. (IHC)