Description

CD160, also known as BY55, is a 27 kD glycoprotein and member of the Ig superfamily. It is anchored to the cell membrane through glycosylphosphatidylinositol (GPI) and forms disulfide-linked multimers. A soluble form of CD160 is secreted by activated CD8⁺ T cells. Expressed by NK, NKT, γ/δ T cells, intestinal intraepithelial T cells and a subset of memory CD8⁺ T cells, CD160 binds both classical and non-classical MHC class I molecules. It is also a ligand for HVEM. CD160 enhances proliferation of activated CD8⁺ T cells and triggers cell cytotoxicity in NK cells.

Formulation

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 microg per million cells in 100 microL volume.  It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Tsujimura K, et al. 2006. Immunol. Lett. 106:48. (FC)