Purified anti-human CD54

Antibodies Single
Sony
HA58
Flow Cytometry
Mouse IgG1, κ
Human
Colonic cancer BM314 cells
2365505
$55.00

Description

CD54 is a 85-110 kD type I transmembrane protein also known as ICAM-1. It is expressed on activated endothelial cells, high endothelial venules, T and B cells, monocytes/macrophages, granulocytes, and dendritic cells. The expression of ICAM-1 can be released from the cell surface. CD54 plays a role in cellular adhesion and is involved in inflammation and leukocyte extravasation. CD54 has also been shown to be the major cellular receptor for rhinovirus. ICAM-1 binds to CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), CD11c/CD18 (p150, 95) as well as hyaluronan and fibrinogen.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Tsujisaki M, et al. 1991. Clin. Exp. Immunol. 85:3.
2. Kanwar JR, et al. 2003. Cancer Gene Ther. 10:468.
3. Kohka H, et al. 1998. J. Leukoc. Biol. 64:519.