PE anti-human CD294 (CRTH2)
Description
CD294, also known as CRTH2, is a seven-transmembrane protein coupled with heterotrimeric G proteins. CRTH2 is the prostaglandin D2 receptor and is expressed by Th2 cells, eosinophils, and basophils. CD294 prevents the apoptosis of Th2 cells and mediates the chemotaxis of CRTH2 expressing cells to the sites of allergic inflammation, such as the asthmatic lung.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 microL to 5 microL per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microL staining volume or per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
References
1. Nagata K, et al. 1999. J. Immunol. 162:1278. (FC)
2. De Fanis U, et al. 2007. Blood 109:4343. (FC)
3. Tsuda H, et al. 2001. Clin. Exp. Immunol. 123:105. (FC)
4. Hamada K, et al. 2004. Allergology International 53:179. (FC)
5. Ohue Y, et al. 2014. Clin Cancer Res. 20:5052. PubMed
6. Marafini I, et al. 2015. PLoS One.10:126291. PubMed