APC/Cy7 anti-human CD1c

Antibodies Single
Sony
L161
Flow Cytometry
Mouse IgG1, κ
Human
2257600
$376.00

Description

CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β2-microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 microL to 5 microL per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microL staining volume or per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. M. del Salamone C, et al. 2001. J. Leukoc. Biol. 70:567.
2. de Fraissinette A, et al. 1988. Exp. Hematol. 16:764.
3. Li D, et al. 2012. J. Exp Med. 209:109. PubMed
4. Jin JO, et al. 2014. PLoS One. 9:104753. PubMed
5. Breton G, et al. 2015. J Exp Med. 212:401. PubMed