Description

CD294, also known as CRTH2, is a seven-transmembrane protein coupled with heterotrimeric G proteins. CRTH2 is the prostaglandin D2 receptor and is expressed by Th2 cells, eosinophils, and basophils. CD294 prevents the apoptosis of Th2 cells and mediates the chemotaxis of CRTH2 expressing cells to the sites of allergic inflammation, such as the asthmatic lung.

Formulation

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Nagata K, et al. 1999. J. Immunol. 162:1278. (FC)
2. De Fanis U, et al. 2007. Blood 109:4343. (FC)
3. Tsuda H, et al. 2001. Clin. Exp. Immunol. 123:105. (FC)
4. Hamada K, et al. 2004. Allergology International 53:179. (FC)