-
Sign In
- Sony Biotechnology
- Sony Biotechnology
CD81 is a 26 kD non-glycosylated member of the tetraspanin superfamily (TM4SF), also known as TAPA-1 (target of an antiproliferative antibody). CD81 is expressed on T and B cells, NK cells, monocytes, dendritic cells, thymocytes, endothelial cells, and fibroblasts. It also has low levels of expression on granulocytes. CD81 induces B cell adhesion via VLA-4 integrin and has been shown to play a role in early T cell development. CD81 associates with several other cell-surface proteins in a multimolecular complex, including CD19, CD21, CD20, CD37, CD53, and CD82 in B cells, and CD4, CD8, and CD82 in T cells.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.
1. Menno C, et al. 2010. J. Clin. Invest. 4:1265.
2. Oren R, et al. 1990. Mol. Cell. Biol. 8:4007. (IP)
3. Clark K, et al. 2004. J. Biol. Chem. 279(19):19401. (IP, WB)
4. Mochida K, et al. 2008. J. Virol. 13:6711.
5. Rappa G, et al. 2014. Mol Cancer Res. 12:1840. PubMed