PE anti-human CD144 (VE-Cadherin)

Antibodies Single
Sony
BV9
Flow Cytometry
Mouse IgG2a, κ
Human
2342530
$290.00

Description

CD144, also known as VE-cadherin and cadherin-5, is a 140 kD glycoprotein which is composed of five extracellular cadherin repeats and a highly conserved cytoplasmic tail region. It is a calcium-dependent transmembrane cell-cell adhesion molecule localized at the intercellular boundaries of endothelial cells, hematopoietic stem cells, and perineurial cells. It functions as a classic cadherin by mediating homophilic adhesion and functions as a plasma membrane attachment site for the cytoskeleton. CD144 is thought to play a role in vascular development, permeability, and remodeling.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 microL to 5 microL per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microL staining volume or per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Almagro S, et al. 2010. Mol. Cell Biol. 30:1703. (WB, IF, IP)
2. Zhang F, et al. 2004. J. Biol. Chem. 279:11760. (WB)
3. Iurlaro M, et al. 2004. Am. J. Pathol. 165:181. (IF)
4. Corada M, et al. 2001. Blood 97:1679. (IP, Block)
5. Kooistra M, et al. 2005. FEBS 579:4966. (Block)
6. Corada M, et al. 2001. Blood 97:1679. (Block)
7. Bouillet L, et al. 2013. Laboratory Investigation 93:1194-11202.