APC anti-human CX3CR1

Antibodies Single
Sony
2A9-1
Flow Cytometry
Rat IgG2b, κ
Human
CX3CR1-EGFP fusion protein
2308045
$145.00

Description

CX3CR1 is a G-protein-coupled seven-transmembrane chemokine receptor, also called GPR13 or V28. It is expressed on NK cells, T cell subset, monocytes/macrophages, dendritic cells, and some malignant epithelial cells. CX3CL1 (known also as fractalkine and neurotactin) is the ligand of CX3CR1. CX3CL1 is a unique transmembrane molecule with a CX3C-motif chemokine domain and a mucin-like stalk. CX3CL1 is expressed by activated-endothelial cells, neurons, and astrocytes. The interaction of CX3CR1 and its ligand mediates firm cell adhesion and migration.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 microL to 5 microL per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microL staining volume or per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Nishimura M, et al. 2002. J. Immunol. 168:6173.
2. Nanki T, et al. 2002. Arthritis Rheum. 46:2878.
3. Kobayashi T, et al. 2007. Inflamm. Bowel Dis. 13:837.
4. Krishnan S, et al. 2013. J Infect Dis. 209:931. PubMed
5. Krow-Lucal ER, et al. 2014. Blood. 123:1897. PubMed
6. Wilson EM, et al. 2014. J Infect Dis. 210:1396. PubMed