Description

CD144, also known as vascular endothelial-cadherin (VE-cadherin), is a 120 kD member of the type II Cadherin family.  It is an endothelial specific hemophilic adhesion molecule involved in endothelial cell survival, migration, contact-dependent growth inhibition, and homophilic adhesion.  VE-cadherin is essential for maintaining the integrity of the endothelial barrier in vivo.

Formulation

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Corada M, et al. 1999. P. Natl. Acad. Sci. USA 96:9815. (WB, Block)
2. Liao F, et al. 2000. Cancer Res. 60:6805. (FC)
3. Crosby CV, et al. 2005. Blood 105:2771. (FC)
4. Liao F, et al. 2002. Cancer Res. 62:2567. (IF)
5. May C, et al. 2005. Blood 105:4337. (epitope)