PE/Cy7 anti-mouse CD127 (IL-7Rα)

Antibodies Single
Sony
A7R34
Flow Cytometry
Rat IgG2a, κ
Mouse
IL-7Ra-IgG1 fusion protein
1275070
$370.00

Description

CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
2. Hashi H, et al. 2001. J. Immunol. 166:3702.
3. Taylor R, et al. 2007. J. Immunol. 178:5659.
4. Mazzon C, et al. 2011. Blood. 118:2733. PubMed
5. Jin J, et al. 2011. J. Immunol. doi:10.4049/jimmunol.1001238. PubMed