Purified anti-human HLA-E
Description
HLA-E is a non-classical MHC class I (MHC-Ib) molecule. It is characterized by limited polymorphism and ubiquitous expression. HLA-E, as other MHC-I molecules, is heterodimerized with β2-microglobulin. HLA-E interacts with CD94/NKG2 receptor to regulate NK cell cytolysis activities.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.
References
1. Lee N, et al. 1998. Proc. Natl. Acad. Sci. USA. 95:5199.
2. Wooden SL, et al. 2005. J. Immunol. 175:1383.
3. Monaco EL, et al. 2008. J. Immunol. 181:5442.
4. Corrah TW, et al. 2011. J. Virol. 85:3367. PubMed