Biotin anti-human CD202b (Tie2/Tek)

Antibodies Single
Sony
33.1 (Ab33)
Flow Cytometry
Mouse IgG1 κ
Human
Recombinant extracellular domain of human Tie2
100 µg
2271020
$208.00

Description

CD202b is a 145 kD type I transmembrane protein, also known as Tie2 or TEK. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie2 binds to Ang-4 as well.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 microg per 106 cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1.Peters KG, et al. 1998. Br. J. Cancer. 77:51.
2.Wong AL, et al. 1997. Circ. Res. 81:567.
3.Lin P, et al. 1998. P. Natl. Acad. Sci. USA 95:8829.