-
Sign In
- Sony Biotechnology
- Sony Biotechnology
CD335, also known as NKp46, is a member of the natural cytotoxicity receptor (NCR) family which triggers cytotoxicity in NK cells. CD335 is directly involved in target cell recognition and lysis, and is exclusively expressed on CD3-CD56+ NK cells, suggesting it is a universal marker for NK cells. NKp46, along with NKp30 and NKp44, is referred to as a natural cytoxicity receptor (NCR) and plays a very important role in killing virus-infected tumor cells and MHC-class I-unprotected cells.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 microL per 106 cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.
1. Nakajima H, et al. 2000. Eur. J. Immunol. 30:3309.
2. Kalberer CP, et al. 2003. Blood 102:127.
3. Chen Y, et al. 2007. J. Immunol. 179:2766.
4. Jarahian M, et al. 2009. J. Virol. 83:8108. PubMed
5. Correia DV, et al. 2011. Blood 118:992. (FC) PubMed
6. Achdout H. et al. 2010. J. Virol. 84:3993.