Biotin anti-human/mouse Integrin β7

Antibodies Single
Sony
FIB504
Flow Cytometry
Rat IgG2a, κ
Other
TK1 cells
50 µg
2206045
$82.00

Description

Integrin β7 is a 130 kD glycoprotein also known as integin βp. It is a member of the Ig superfamily. In association with integrin α4 or αE chain, β7 forms α4/β7 or αE/β7 heterodimer. α4/β7 (CD49d/β7, LPAM-1) is expressed on the majority of peripheral lymphocytes, on small subsets of thymocytes, and bone marrow progenitors. a4/β7 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion and some hematopoietic progenitor cells migration. αE/β7 (CD103/β7,αIEL/β7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/β7 complex is thought to play a role in lymphocyte retention via interaction with its ligand E-Cadherin.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Andrew DP, et al. 1994. J. Immunol. 153:3847. (Block)
2. Berlin C, et al. 1993. Cell 74:185.
3. Rott LS, et al. 1996. J. Immunol. 156:3727. (Block)
4. Rivera-Nieves J, et al. 2005. J. Immunol. 174:2343. (Block)
5. Ohmori K, et al. 2009. J. Immunol. 182:2835. PubMed
6. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
7. Yamada D, et al. 2014. J. Immunol. 192:4112. PubMed