PE/Cy7 anti-mouse CD117 (c-kit)

Antibodies Single
Sony
ACK2
Flow Cytometry
Rat IgG2b, κ
Mouse
Murine IL-3 dependent mast cells
1275555
$75.00

Description

CD117 is a 145 kD immunoglobulin superfamily member, also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Yoshinaga K, et al. 1991. Development 113:689.
2. Broudy VC, et al. 1996. Blood 88:75.
3. Louvet C, et al. 2008. Proc. Natl. Acad. Sci. USA 105:18895.
4. Gong Y, et al. 2014. PLoS One. 9:95898. PuMed