FITC anti-human β2-microglobulin

Antibodies Single
Sony
2M2
Flow Cytometry
Mouse IgG1, κ
Human
Purified human β2-microglobulin
100 tests
2181520
$226.00

Description

β2-microglobulin (β2M) is a 12 kD nonpolymorphic Ig like protein. It is a non-membrane-anchored glycoprotein and is noncovalently associated with 39-44 kD polymorphic heavy chains of MHC class I molecules to form HLA class I antigen complex. In association with HLA class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role both in governing MHC class I molecules stability and in promoting antigen binding and presenting the antigen to CD3/TCR complex of CD8+ T cells.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 microL to 5 microL per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microL staining volume or per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Meissner TB, et al. 2010. Proc Natl Acad Sci USA. PubMed
2. Rizvi SM, et al. 2011. J. Immunol. 186:2309. PubMed
3. Meissner TB, et al. 2012. J Immunol. 188:4951. PubMed.