Alexa Fluor® 488 anti-human CD206 (MMR)
Description
Macrophage mannose receptor (MMR) is a 162-175 kD type I membrane protein also known as CD206, MRC1, or mannose receptor (MR). It is a pattern recognition receptor (PRR) that belongs to C-type lectin superfamily. MMR is expressed on macrophages, dendritic cells, and hepatic or lymphatic endothelial cells, but not on monocytes. MMR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine. MMR mediates endocytosis and phagocytosis, induces activation of macrophages and antigen presentation, plays an important role in host defense, and provides a link between innate and adaptive immunity.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 microL per million cells in 100 microL volume or 5 microL per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.
References
1. Noorman F, et al. 1997. J. Leukocyte Biol. 61:63. (WB, IHC, Block)
2. Barrett-Bergshoeff M, et al. 1997. Thromb Haemost. 77:718. (Block)
3. Kato M, et al. 2007. J. Immunol. 179:6052. (IF)
4. Nguyen A, et al. 2014. J Biol Chem. 289:1688. PubMed
5. O'Regan NL, et al. 2014. PLoS Negl Trop Dis. 8:3206. PubMed