APC anti-human CD206 (MMR)

Antibodies Single
Sony
15-2
Flow Cytometry
Mouse IgG1, κ
Human
Purified human mannose receptor
2205550
$306.00

Description

Macrophage mannose receptor (MMR) is a 162-175 kD type I membrane protein also known as CD206, MRC1, or mannose receptor (MR). It is a pattern recognition receptor (PRR) that belongs to C-type lectin superfamily. MMR is expressed on macrophages, dendritic cells, and hepatic or lymphatic endothelial cells, but not on monocytes. MMR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine. MMR mediates endocytosis and phagocytosis, induces activation of macrophages and antigen presentation, plays an important role in host defense, and provides a link between innate and adaptive immunity.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 microL to 5 microL per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microL staining volume or per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Noorman F, et al. 1997. J. Leukocyte Biol. 61:63. (WB, IHC, Block)
2. Barrett-Bergshoeff M, et al. 1997. Thromb Haemost. 77:718. (Block)
3. Kato M, et al. 2007. J. Immunol. 179:6052. (IF)
4. Nguyen A, et al. 2014. J Biol Chem. 289:1688. PubMed
5. O'Regan NL, et al. 2014. PLoS Negl Trop Dis. 8:3206. PubMed