Purified anti-mouse CD197 (CCR7)

Antibodies Single
Sony
4B12
Other
Rat IgG2a, κ
Mouse
Mouse CCR7 transfected RBL-2H3 cells
50 µg
1200505
$134.00

Description

CD197 is also known as C-C chemokine receptor 7 (CCR7) or EBI-1. CCR7 is a G-coupled rhodopsin-like member of the GPCR superfamily with a predicted molecular weight of 43 kD that is expressed on hematopoietic stem cells, most naive T cells, some memory T cells, B subset, and mature dendritic cells. CCR7 is a receptor for the chemokines CCL19 (MIP3 β) and SLC (6CKine, Exodus-2, TCA-4, CCL21) that plays a role in thymocytes development, T cell adhesion at intestinal sites, the homeostatic recirculation of memory T cells, and chemotaxis.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 microg per 106 cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Ohl L, et al. 2004. Immunity 21:279.
2. Ritter U, et al. 2004. J. Leukocyte Biol. 76:472.
3. Lan YY, et al. 2005. Am. J. Transplant. 5:2649. (FC)
4. Lee JH, et al. 2007. J. Immunol. 178:301. (FC) PubMed
5. Kurooka M and Kaneda Y. 2007. Cancer Res. 67:227. (FC) PubMed
6. Thompson BD. 2007. J. Biol. Chem. 282:9547. (FC)
7. Sakai N, et al. 2006. P. Natl. Acad. Sci. USA 103:14098. (FC)
8. Turnquist HR, et al. 2007. J. Immunol. 178:7018. (FC)
9. Hwang IY, et al. 2007. J. Immunol. 179:439. (FC) PubMed
10. Kang SG, et al. 2007. J. Immunol. 179:3724.
11. Mao A et al. 2005. J. Immunol. 175:5146. PubMed
12. Allende ML, et al. 2008. FASEB J. 22:307. PubMed
13. Kang SG, et al. 2007. J. Immunol. 179:3724. PubMed
14. Chen H, et al. 2005. J. Immunol. 175:591. PubMed
15. Florido M, et al. 2009. Immunobiology. 214:643. PubMed
16. Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed
17. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed