APC/Fire™ 750 anti-mouse CD193 (CCR3)

Antibodies Single
Sony
J073E5
Flow Cytometry
Rat IgG2a, κ
Mouse
Mouse CCR3-transfectants
1322605
$182.00

Description

CD193, also known as CC-chemokine receptor 3 (CCR3), CC CKR3, MIP1-α receptor like-2, and eotaxin receptor, is a member of the G protein-coupled, seven transmembrane receptor family. It binds to the CC chemokines eotaxin, eotaxin-2, and eotaxin-3 with high affinity. CD193 has also been reported to bind RANTES, MCP-3, and MCP-4 with low affinity. CD193 is expressed on mouse eosinophils, basophils, mast cells, mononuclear phagocytes, platelets, hematopoietic progenitor cells, and keratinocytes. It is thought to play a role in allergic diseases such as bronchial asthma and allergic rhinitis. CD193 also function as a co-receptor for HIV-1 and HIV-2, and the binding of eotaxin with CD193 has been shown to inhibit HIV infection in some cell types.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.