Biotin anti-mouse CD134 (OX-40)

Antibodies Single
Sony
OX-86
Flow Cytometry
Rat IgG1, κ
Mouse
Recombinant mouse OX-40-CD4 chimeric protein
50 µg
1197015
$82.00

Description

CD134 is a type I integral membrane protein also known as OX-40, ACT35, and tumor necrosis factor receptor superfamily member 4 (TNFRSF4). This receptor is expressed on activated CD4+ and CD8+ T cells and B cells. The OX-40 receptor binds to the OX-40 ligand (CD252) to provide a costimulatory signal that is independent of CD28. Blockade of OX40-OX40 ligand interactions has been shown to ameliorate experimental EAE and inflammatory bowel disease, which implies that these interactions are important in the pathogenesis of some autoimmune diseases.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 microg per 106 cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Higgins LM, et al. 1999. J. Immunol. 162:486. (FC, IHC)
2. Al-Shamkhani A, et al. 1996. Eur. J. Immunol. 26:1695. (Costim)
3. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed