Purified anti-mouse CD218a (IL-18Rα)

Antibodies Single
Sony
A17071D
Flow Cytometry
Rat IgG2b, κ
Mouse
Recombinant mouse CD218a
500 µg
1389510
$472.00

Description

The IL-18 receptor (IL-18R) complex is composed of two known chains, IL-18 receptor α (IL-18Rα) and IL-18 receptor β (IL-18Rβ). IL-18Rα (IL-1R5) is an IL-1 receptor super family member. It was originally described as IL-1 receptor-related protein (IL-1Rrp) because of its homology with the IL-1/Toll receptor family. IL-18Rα is the extracellular binding domain of the IL-18 receptor complex. It is expressed on the majority of peripheral CD4+ T cells, Th1 cells, and reciprocally repressed during Th2 development. The expression of IL-18Rα is induced by an IL-12/Stat4 pathway and inhibited by IL-4/Stat6 pathway. Binding of IL-18Rα together with IL-18β to proinflammatory cytokine IL-18 plays an important role in innate and autoimmune responses.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.