Alexa Fluor® 647 anti-mouse EOMES

Antibodies Single
Sony
W17001A
Intracellular Flow Cytometry
Rat IgG2b, λ
Mouse
Mouse EOMES recombinant protein (463-707 a.a.) expressed in E. coli.
25 µg
1388515
$157.00

Description

Eomesodermin, or EOMES, is a transcription factor in the T-box family. During embryonic development, EOMES is crucial in regulating trophoblast differentiation, gastrulation, mesoderm delamination, and development of the cerebral cortex. In the immune system, EOMES is involved in the activation, migration, and differentiation of CD8+ T cells. In cooperation with another T-box transcription factor, T-bet, EOMES induces production of IFN-γ and enhances cytotoxic activities of effector CD8+ T cells. EOMES has been shown to be required to maintain long-term memory of CD8+ T cells and is important for homeostasis of memory and effector T cells.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.