PE/Dazzle™ 594 anti-human Ganglioside GD2

Antibodies Single
Sony
14G2a
Flow Cytometry
Mouse IgG2a, κ
Human
Neuroblastoma cell line LAN-1
2386600
$436.00

Description

Ganglioside GD2 is a sialic acid-containing glycosphingolipid involved in cell attachment to the extracellular matrix. Expression of GD2 in normal tissue is restricted to cells from the central nervous system, peripheral nerves, skin melanocytes, and mesenchymal stem cells. However GD2 is highly expressed by tumors of neuro-ectodermal origin such as melanomas, gliomas, neuroblastomas, and small cell lung carcinoma. GD2 has been proposed as a marker for some cancer stem cells.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

* PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.

References

  1. Mujoo K, et al. 1989. Cancer Res. 49:2857. (Cyt)
  2. Kowalczyk A, et al. 2009. Cancer Lett. 281:171. (Apop, Cyt)
  3. Battula VL, et al. 2012. J. Clin. Invest. 122:2066. (FC)