Purified anti-mouse NK-1.1

Antibodies Single
Sony
S17016D
Flow Cytometry
Mouse IgG2a, κ
Mouse
NK-1+ cells from mouse spleen and bone marrow
500 µg
1382510
$152.00

Description

NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

  1. Lanier LL. 1997. Immunity 6:371.
  2. Yokoyama WM, Seaman WE. 1993. Annu. Rev. Immunol. 11:613.
  3. Koo GC, et al. 1986. J. Immunol. 137:3742.
  4. Giorda R, Trucco M. 1991. J. Immunol. 147:1701.