PE/Dazzle™ 594 anti-mouse CD39

Antibodies Single
Sony
Duha59
Flow Cytometry
Rat IgG2a, κ
Mouse
CD39 cDNA expression vector
1319055
$176.00

Description

CD39, nucleoside triphosphate diphosphohydrolase-1 (NTPDase 1), is an ectoenzyme that degrades ATP to AMP. It is a member of the ectonucleoside triphosphate dihydrolases (E-NTPDases), which are involved in regulation of extracellular nucleotide catabolism and controlling the extracellular nucleoside triphosphate pool (NTP). CD39 is the dominant member of this family in the immune system, and is involved in suppression of inflammation and control of platelet activation. CD39 is expressed on B cells, dendritic cells, and a subset of T cells, including regulatory T cells and memory T cells. The coordinated expression of CD39/CD73 on Tregs and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

* PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.

References

1. Borsellino G, et al. 2007. Blood 110:1225.
2. Deaglio S, et al. 2007. J. Exp. Med. 204:1257.
3. Bynoe MS, et al. 2008. Trends Immunol. 29:99.
4. Ndhlovu LC, et al. 2010